Regional cerebral tau predicts decline in everyday functioning across the Alzheimer's disease spectrum.

ABSTRACT:

Background

Emerging difficulty performing cognitively complex everyday tasks, or 'instrumental activities of daily living' (IADL) may be an early clinical sign of Alzheimer's disease (AD). We aimed to investigate how changes over time in everyday functioning relate to cerebral tau burden across the AD clinical spectrum.

Methods

We included 581 participants (73.9 ± 7.6 years old; 52% female) from the Alzheimer's Disease Neuroimaging Initiative who underwent tau positron emission tomography (PET) and completed at least two assessments of the Functional Activities Questionnaire (FAQ). Participants were classified as cognitively normal (n = 334) or symptomatic (n = 247). We analyzed the association between longitudinal FAQ scores and baseline tau in six temporal, parietal, and f

SUBMITTER: Dubbelman MA 

PROVIDER: S-EPMC10320884 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature