Reduced intestinal lipid absorption improves glucose metabolism in aged G2-Terc knockout mice.

ABSTRACT:

Background

Biological aging is an important factor leading to the development of pathologies associated with metabolic dysregulation, including type 2 diabetes, cancer, cardiovascular and neurodegenerative diseases. Telomere length, a central feature of aging, has additionally been identified as inversely associated with glucose tolerance and the development of type 2 diabetes. However, the effects of shortened telomeres on body weight and metabolism remain incompletely understood. Here, we studied the metabolic consequences of moderate telomere shortening using second generation loss of telomerase activity in mice.

Results

Aged male and female G2 Terc-/- mice and controls were characterized with respect to body weight and composition, glucose homeostasis, insulin sensitivit

SUBMITTER: Liu X 

PROVIDER: S-EPMC10320900 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature