A novel polypeptide CAPG-171aa encoded by circCAPG plays a critical role in triple-negative breast cancer.

ABSTRACT:

Background

The treatment of Triple-negative breast cancer (TNBC) has always been challenging due to its heterogeneity and the absence of well-defined molecular targets. The present study aims to elucidate the role of protein-coding circRNAs in the etiology and carcinogenesis of TNBC.

Methods

CircRNA expression data in TNBC (GEO: GSE113230, GSE101123) were reanalyzed and then circCAPG was selected for further study. To identify the polypeptide-coding function of circCAPG, a series of experiments, such as Mass spectrometry and dual-luciferase reporter assays were conducted. Cell proliferation, apoptosis and metastasis parameters were determined to investigate the cancerous functions CAPG-171aa plays in both TNBC organoids and nude mice. Mechanistically, the relation between CA

SUBMITTER: Song R 

PROVIDER: S-EPMC10320902 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature