The prognostic value and immune landscaps of m6A/m5C-related lncRNAs signature in the low grade glioma.

ABSTRACT:

Background

N6-methyladenosine (m6A) and 5-methylcytosine (m5C) are the main RNA methylation modifications involved in the oncogenesis of cancer. However, it remains obscure whether m6A/m5C-related long non-coding RNAs (lncRNAs) affect the development and progression of low grade gliomas (LGG).

Methods

We summarized 926 LGG tumor samples with RNA-seq data and clinical information from The Cancer Genome Atlas and Chinese Glioma Genome Atlas. 105 normal brain samples with RNA-seq data from the Genotype Tissue Expression project were collected for control. We obtained a molecular classification cluster from the expression pattern of sreened lncRNAs. The least absolute shrinkage and selection operator Cox regression was employed to construct a m6A/m5C-related lncRNAs prognostic s

SUBMITTER: Li R 

PROVIDER: S-EPMC10320943 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature