The use of alpha 1 thymosin as an immunomodulator of the response against SARS-Cov2.

ABSTRACT:

Background

Since the beginning of SARS-CoV2 pandemic, the mortality rate among elderly patients (60-90 years) has been around 50%, so age has been a determining factor of a worse COVID-19 prognosis. Associated with age, the thymic function involution and depletion plays an important role, that could be related to a dysregulated and ineffective innate and adaptive immune response against SARS-CoV2. Our study aims to further in vitro effect of human Thymosin-alpha-1 (α1Thy) treatment on the immune system in population groups with different thymic function levels in the scenario of SARS-CoV2 infection.

Results

Activation markers such as CD40, CD80 and TIM-3 were upregulated in α1Thy presence, especially in plasmacytoid dendritic cells (pDCs) and, with increased TNFα production

SUBMITTER: Espinar-Buitrago MS 

PROVIDER: S-EPMC10320944 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature