Whole genome and RNA sequencing analyses for 254 Taiwanese hepatocellular carcinomas.

ABSTRACT:

Background

Comprehensive and integrative analysis of hepatocellular carcinoma (HCC) is important. In this study, we explored Taiwanese HCCs using multi-omics analyses.

Methods

We analyzed 254 HCCs by whole genome sequencing and total RNA sequencing, and then used bioinformatic tools to analyze genomic and transcriptomic alterations in coding and non-coding sequences to explore the clinical importance of each sequence.

Results

The frequencies of the five most commonly mutated cancer-related genes were TERT, TP53, CTNNB1, RB1, and ARID1A. Genetic alteration frequencies influenced the etiology of HCC; some alterations were also correlated with clinicopathological conditions. Many cancer-related genes had copy number alterations (CNAs) and structure variants (SVs) that ch

SUBMITTER: Chang YS 

PROVIDER: S-EPMC10320951 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature