Role of necroptosis and immune infiltration in preeclampsia: novel insights from bioinformatics analyses.

ABSTRACT:

Background

Preeclampsia (PE) is a serious pregnancy complication that can adversely affect the mother and fetus. Necroptosis is a recently discovered new form of programmed cell death involved in the pathological process of various pregnancy complications. Our study aimed to identify the necroptosis-related differentially expressed genes (NRDEGs), create a diagnosis model and related disease subtypes model based on these genes, and further investigate their relationship with immune infiltration.

Methods

In this study, we identified NRDEGs by analyzing data from various databases, including Molecular Signatures, GeneCards, and Gene Expression Omnibus (GEO). Using minor absolute shrinkage and selection operator (LASSO) and logistic Cox regression analysis, we developed a novel

SUBMITTER: He L 

PROVIDER: S-EPMC10320970 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature