Expression of NEAT1 can be used as a predictor for Dex resistance in multiple myeloma patients.

ABSTRACT:

Objective

Multiple myeloma is a heterogeneous disorder and the intratumor genetic heterogeneity contributes to emergency of drug resistance. Dexamethasone has been used clinically for decades for MM. Nevertheless, their use is severely hampered by the risk of developing side effects and the occurrence of Dex resistance. LncRNA NEAT1 plays a oncogenic role and participates in drug resistance in many solid tumors. Therefore, we investigated a potential usefulness of this molecular as a biomarker for diagnosis of MM and possible correlations of NEAT1 expression with drug resistance and prognosis.

Methods

Bone marrow and peripheral blood mononuclear cells samples were collected from 60 newly diagnosed MM patients. The expression of NEAT1expression level were detected by quantita

SUBMITTER: Ren Y 

PROVIDER: S-EPMC10320976 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature