Oral-microbiome-derived signatures enable non-invasive diagnosis of laryngeal cancers.

ABSTRACT:

Background

Recent studies have uncovered that the microbiota in patients with head and neck cancers is significantly altered and may drive cancer development. However, there is limited data to explore the unique microbiota of laryngeal squamous cell carcinoma (LSCC), and little is known regarding whether the oral microbiota can be utilized as an early diagnostic biomarker.

Methods

Using 16S rRNA gene sequencing, we characterized the microbiome of oral rinse and tissue samples from 77 patients with LSCC and 76 control patients with vocal polyps, and then performed bioinformatic analyses to identify taxonomic groups associated with clinicopathologic features.

Results

Multiple bacterial genera exhibited significant differences in relative abundance when stratifying by hi

SUBMITTER: Yu S 

PROVIDER: S-EPMC10320982 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature