Risk factors for lung function decline in systemic sclerosis-associated interstitial lung disease in a large single-centre cohort.

ABSTRACT:

Objectives

The aim of this study was to identify risk factors of percent predicted forced vital capacity (ppFVC) decline in patients with SSc-associated interstitial lung disease (SSc-ILD).

Methods

We identified 484 patients with SSc who had HRCT Chest, of which 312 with ILD. Those with serial pulmonary function tests were included in a longitudinal analysis (n = 184). Linear mixed effect models were fitted to assess the decline in ppFVC over time, and to explore the effect of demographics and baseline characteristics on ppFVC decline.

Results

The majority of SSc-ILD patients were female (76.3%) and 51.3% had diffuse cutaneous subset. The mean (s.d.) age was 53.6 (12.7) years, median disease duration since first non-RP symptoms was 2.6 years, and 48.4% of the patients

SUBMITTER: Ramahi A 

PROVIDER: S-EPMC10321078 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature