Type I interferon and neutrophil transcripts in lupus nephritis renal biopsies: clinical and histopathological associations.

ABSTRACT:

Objectives

To investigate the expression of type I IFN (IFN-I) and neutrophil transcripts in kidney tissue from patients with different classes of LN and their association with distinct clinical and histopathological features.

Methods

Quantitation of IFN-I, defensin-α3 and formyl peptide receptor-like 1 (FPRL-1) transcripts was performed in kidney biopsy tissue from 24 patients with various classes of LN (6 class III, 14 class IV, 4 class V) and 3 control samples. Patient demographics, glomerular filtration rate (eGFR) and histopathological characteristics, including activity and chronicity indices, were analysed.

Results

IFNα2 and IFNβ transcripts were overexpressed in renal tissues from patients with proliferative forms of LN (III/IV) compared with patients with mem

SUBMITTER: Mavragani CP 

PROVIDER: S-EPMC10321084 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature