Imaging the columnar functional organization of human area MT+ to axis-of-motion stimuli using VASO at 7 Tesla.

ABSTRACT: Cortical columns of direction-selective neurons in the motion sensitive area (MT) have been successfully established as a microscopic feature of the neocortex in animals. The same property has been investigated at mesoscale (<1 mm) in the homologous brain area (hMT+, V5) in living humans by using ultra-high field functional magnetic resonance imaging (fMRI). Despite the reproducibility of the selective response to axis-of-motion stimuli, clear quantitative evidence for the columnar organization of hMT+ is still lacking. Using cerebral blood volume (CBV)-sensitive fMRI at 7 Tesla with submillimeter resolution and high spatial specificity to microvasculature, we investigate the columnar functional organization of hMT+ in 5 participants perceiving axis-of-motion stimuli for both blood oxygena

SUBMITTER: Pizzuti A 

PROVIDER: S-EPMC10321107 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature