Association between anti-SSSCA1 antibodies and cancer in systemic sclerosis.

ABSTRACT:

Objective

To define the clinical phenotype of SSc patients with antibodies against Sjogren's syndrome (SS)/scleroderma autoantigen 1 (SSSCA1), and to examine the association between these antibodies and cancer in SSc patients.

Methods

We conducted a case-control study using data from 209 patients with SSc and cancer, and 205 SSc patients without cancer. All were randomly selected from the Johns Hopkins Scleroderma Center Research Registry. Antibodies against SSSCA1 were assayed by immunoprecipitation of 35S-methionine-labelled protein generated by in vitro transcription and translation. We performed logistic regression analysis to examine the relationship between anti-SSSCA1 antibodies and cancer.

Results

Among the 414 study patients, 31 (7%) were anti-SSSCA1 antibody

SUBMITTER: Wallwork RS 

PROVIDER: S-EPMC10321112 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature