Autophagy-related genes affect the survival of multiple myeloma patients depending on chromosomal abnormality.

ABSTRACT:

Background

Targeting autophagy at gene level may be promising in multiple myeloma (MM) treatment depending on chromosomal abnormality (ABN) status.

Objectives

We aimed to investigate the role of ABN on survival of MM patients and to identify prognosis related autophagy-related genes (ARGs) for patients with or without ABN.

Methods

Gene intensity values of 222 ARG for 548 MM patients were obtained from the Affymetrix Human Genome U133 Plus 2.0 Array (GPL570) platform containing 54,675 probes (GSE24080). A dataset containing data from 1576 MM patients with 1q21 amplification (GSE4204, GSE4452, GSE4581, and GSE2658) was used for validation. Survival analysis of the patients was analyzed using univariate and multivariate Cox regression method with the help of R3.53 progra

SUBMITTER: Ayna Duran G 

PROVIDER: S-EPMC10321186 | biostudies-literature | 2022 Oct

REPOSITORIES: biostudies-literature