Maternal microbiome disturbance induces deficits in the offspring's behaviors: a systematic review and meta-analysis.

ABSTRACT: Recent evidence has suggested that changes in maternal gut microbiota in early life may generate neurobiological consequences associated with psychiatric-related abnormalities. However, the number of studies on humans investigating this problem is limited, and preclinical findings sometimes conflict. Therefore, we run a meta-analysis to examine whether maternal microbiota disturbance (MMD) during neurodevelopment might affect the offspring during adulthood. We found thirteen studies, from a set of 459 records selected by strategy registered on PROSPERO (#289224), to target preclinical studies that evaluated the behavioral outcomes of the rodents generated by dams submitted to perinatal enteric microbiota perturbation. The analysis revealed a significant effect size (SMD = -0.51, 95% CI = -

SUBMITTER: Hassib L 

PROVIDER: S-EPMC10321199 | biostudies-literature | 2023 Jan-Dec

REPOSITORIES: biostudies-literature