β-amyloid binds to microglia Dectin-1 to induce inflammatory response in the pathogenesis of Alzheimer's disease.

ABSTRACT: Microglia-mediated neuroinflammation is closely related to the development of Alzheimer's disease (AD). In the early stages of the inflammation response, pattern recognition receptors (PRRs) play a key role in clearing damaged cells and defending against infection by recognizing endogenous and exogenous ligands. However, the regulation of pathogenic microglial activation and its role in AD pathology remains poorly understood. Here we showed that a pattern recognition receptor called Dectin-1, expressed on microglia, mediates the pro-inflammatory responses of beta-amyloid (Aβ). Knockout of Dectin-1 reduced Aβ1-42 (Aβ₄₂)-induced microglial activation, inflammatory responses, and synaptic and cognitive deficits in Aβ₄₂-infused AD mice. Similar results were obtained in th

SUBMITTER: Zhao X 

PROVIDER: S-EPMC10321287 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature