Polymyxin B complexation enhances the antimicrobial potential of graphene oxide.

ABSTRACT:

Introduction

The antibacterial activity of graphene oxide (GO) has been widely explored and tested against various pathogenic bacterial strains. Although antimicrobial activity of GO against planktonic bacterial cells was demonstrated, its bacteriostatic and bactericidal effect alone is not sufficient to damage sedentary and well protected bacterial cells inside biofilms. Thus, to be utilized as an effective antibacterial agent, it is necessary to improve the antibacterial activity of GO either by integration with other nanomaterials or by attachment of antimicrobial agents. In this study, antimicrobial peptide polymyxin B (PMB) was adsorbed onto the surface of pristine GO and GO functionalized with triethylene glycol.

Methods

The antibacterial effects of the resulting mater

SUBMITTER: Pandit S 

PROVIDER: S-EPMC10321305 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature