Boldine modulates glial transcription and functional recovery in a murine model of contusion spinal cord injury.

ABSTRACT: Membrane channels such as those formed by connexins (Cx) and P2X₇ receptors (P2X₇R) are permeable to calcium ions and other small molecules such as adenosine triphosphate (ATP) and glutamate. Release of ATP and glutamate through these channels is a key mechanism driving tissue response to traumas such as spinal cord injury (SCI). Boldine, an alkaloid isolated from the Chilean boldo tree, blocks both Cx and Panx1 hemichannels (HCs). To test if boldine could improve function after SCI, boldine or vehicle was administered to treat mice with a moderate severity contusion-induced SCI. Boldine led to greater spared white matter and increased locomotor function as determined by the Basso Mouse Scale and horizontal ladder rung walk tests. Boldine treatment reduced immunostain

SUBMITTER: Toro CA 

PROVIDER: S-EPMC10321410 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature