The genetic network underlying the evolution of pathogenicity in avian Escherichia coli.

ABSTRACT:

Introduction

Colibacillosis is a worldwide prevalent disease in poultry production linked to Escherichia coli strains that belong to the avian pathogenic E. coli (APEC) pathotype. While many virulence factors have been linked to APEC isolates, no single gene or set of genes has been found to be exclusively associated with the pathotype. Moreover, a comprehensive description of the biological processes linked to APEC pathogenicity is currently lacking.

Methods

In this study, we compiled a dataset of 2015 high-quality avian E. coli genomes from pathogenic and commensal isolates, based on publications from 2000 to 2021. We then conducted a genome-wide association study (GWAS) and integrated candidate gene identification with available protein-protein intera

SUBMITTER: Palmieri N 

PROVIDER: S-EPMC10321414 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature