Whole-genome Duplications and the Long-term Evolution of Gene Regulatory Networks in Angiosperms.

ABSTRACT: Angiosperms have a complex history of whole-genome duplications (WGDs), with varying numbers and ages of WGD events across clades. These WGDs have greatly affected the composition of plant genomes due to the biased retention of genes belonging to certain functional categories following their duplication. In particular, regulatory genes and genes encoding proteins that act in multiprotein complexes have been retained in excess following WGD. Here, we inferred protein-protein interaction (PPI) networks and gene regulatory networks (GRNs) for seven well-characterized angiosperm species and explored the impact of both WGD and small-scale duplications (SSDs) in network topology by analyzing changes in frequency of network motifs. We found that PPI networks are enriched in WGD-derived genes asso

SUBMITTER: Almeida-Silva F 

PROVIDER: S-EPMC10321489 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature