In silico study to predict promiscuous peptides for immunodiagnosis of cystic echinococcosis.

ABSTRACT:

Background

Cystic echinococcosis (CE), caused by Echinococcus granulosus, is a major zoonotic disease that causes significant human morbidity and mortality. This cosmopolitan disease is difficult to diagnose, treat, and control. So far, crude extracts of hydatid cyst fluid containing antigen B or antigen 5 have been used as the primary antigenic source for its immunodiagnosis. The main issue is that it reacts with sera from people infected with other helminths. There is currently no standard, specific, or sensitive test for disease diagnosis, and no human vaccine has been reported.

Aims and objectives

Considering the need for efficient immunization and/or immunodiagnosis, six E. granulosus antigens, antigen 5, antigen B, heat shock proteins such as Hsp-8 and Hs

SUBMITTER: Chauhan V 

PROVIDER: S-EPMC10321577 | biostudies-literature | 2023 Jan-Jun

REPOSITORIES: biostudies-literature