Construction and validation of a novel cuproptosis-mitochondrion prognostic model related with tumor immunity in osteosarcoma.

ABSTRACT:

Background

The purpose of this study was to develop a new prognostic model for osteosarcoma based on cuproptosis-mitochondrion genes.

Materials and methods

The data of osteosarcoma were obtained from TARGET database. By using Cox regression and LASSO regression analysis, a novel risk score was constructed based on cuproptosis-mitochondrion genes. Kaplan-Meier, ROC curve and independent prognostic analyses were performed to validate the risk score in GSE21257 dataset. Then, a predictive nomogram was constructed and further validated by calibration plot, C-index and ROC curve. Based on the risk score, all patients were divided into high-risk and low-risk group. GO and KEGG enrichment, immune correlation and drug sensitivity analyses were performed between groups. Real-time qua

SUBMITTER: Feng J 

PROVIDER: S-EPMC10321638 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature