De-Novo Depression, Prophylactic Antidepressant, and Survival in Patients With Head and Neck Cancer.

ABSTRACT:

Objective

To study the association between the development of moderate or greater depression during curative-intent therapy and overall survival (OS) in patients with stages II-IV head and neck cancer (HNC).

Methods

In this secondary analysis of a randomized double-blind placebo-controlled trial, of 148 eligible participants diagnosed with stages II-IV HNC but without baseline depression, 125 were evaluable and were randomly allocated to prophylactic escitalopram oxalate (n = 60) or placebo (n = 65). Participants were followed for development of moderate or greater depression, using Quick Inventory of Depressive Symptomatology-Self Report (QIDS-SR, range 0-27, score ≥11 indicated moderate or greater depression), and were stratified by demographics; cancer site and stage; and

SUBMITTER: Panwar A 

PROVIDER: S-EPMC10321851 | biostudies-literature | 2023 Apr

REPOSITORIES: biostudies-literature