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Treatment of Cancer-Associated Thrombosis: Recent Advances, Unmet Needs, and Future Direction.

ABSTRACT: Cancer-associated thrombosis, with the incidence rising over the years, is associated with significant morbidity and mortality in patients with cancer. Recent advances in the treatment of cancer-associated venous thromboembolism (VTE) include the introduction of direct oral anticoagulants (DOACs), which provide a more convenient and effective option than low-molecular-weight heparin (LMWH). Nonetheless, important unmet needs remain including an increased risk of bleeding in certain patient subgroups such as those with gastroesophageal cancer, concerns about drug-drug interactions, and management of patients with severe renal impairment. Although DOACs are more convenient than LMWH, persistence can decline over time. Factor XI inhibitors have potential safety advantages over DOACs because factor XI appears to be essential for thrombosis but not hemostasis. In phase II trials, some factor XI inhibitors were superior to enoxaparin for the prevention of VTE after knee replacement surgery without increasing the risk of bleeding. Ongoing trials are assessing the efficacy and safety of factor XI inhibitors for the treatment of cancer-associated VTE.

SUBMITTER: Wang TF

PROVIDER: S-EPMC10322141 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Treatment of Cancer-Associated Thrombosis: Recent Advances, Unmet Needs, and Future Direction.

Wang Tzu-Fei TF Khorana Alok A AA Agnelli Giancarlo G Bloomfield Dan D Bonaca Marc P MP Büller Harry R HR Connors Jean M JM Goto Shinya S Jing Zhi-Cheng ZC Kakkar Ajay K AK Khder Yasser Y Raskob Gary E GE Soff Gerald A GA Verhamme Peter P Weitz Jeffrey I JI Carrier Marc M

The oncologist 20230701 7

Cancer-associated thrombosis, with the incidence rising over the years, is associated with significant morbidity and mortality in patients with cancer. Recent advances in the treatment of cancer-associated venous thromboembolism (VTE) include the introduction of direct oral anticoagulants (DOACs), which provide a more convenient and effective option than low-molecular-weight heparin (LMWH). Nonetheless, important unmet needs remain including an increased risk of bleeding in certain patient subgr ...[more]

PMID: 37171998

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Dataset Information

Treatment of Cancer-Associated Thrombosis: Recent Advances, Unmet Needs, and Future Direction.

Publications

Treatment of Cancer-Associated Thrombosis: Recent Advances, Unmet Needs, and Future Direction.

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