Association between biologically effective dose and local control after stereotactic body radiotherapy for metastatic sarcoma.

ABSTRACT:

Introduction

Stereotactic body radiation therapy (SBRT) is increasingly utilized for patients with recurrent and metastatic sarcoma. SBRT affords the potential to overcome the relative radioresistance of sarcomas through delivery of a focused high biological effective dose (BED) as an alternative to invasive surgery. We report local control outcomes after metastatic sarcoma SBRT based on radiation dose and histology.

Methods

From our IRB-approved single-institution registry, all patients treated with SBRT for metastatic sarcoma between 2014 and 2020 were identified. Kaplan-Meier analysis was used to estimate local control and overall survival at 1 and 2 years. A receiver operating characteristic (ROC) curve was generated to determine optimal BED using an α/β ratio of 3. Loca

SUBMITTER: Somasundaram E 

PROVIDER: S-EPMC10322177 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature