Neighborhood disadvantage is associated with KRAS-mutated non-small cell lung cancer risk.

ABSTRACT:

Purpose

It remains unclear why individuals living in disadvantaged neighborhoods have shorter non-small cell lung cancer (NSCLC) survival. It is possible that living in these deprived areas is linked with increased risk of developing aggressive NSCLC biology. Here, we explored the association of somatic KRAS mutations, which are associated with shorter survival in NSCLC patients, and 11 definitions of neighborhood disadvantage spanning socioeconomic and structural environmental elements.

Methods

We analyzed data from 429 NSCLC patients treated at a Comprehensive Cancer Center from 2015 to 2018. Data were abstracted from medical records and each patient's home address was used to assign publicly available indices of neighborhood disadvantage. Prevalence Ratios (PRs) for the p

SUBMITTER: Wing SE 

PROVIDER: S-EPMC10322188 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature