Identifying childhood leukemia with an excess of hematological malignancies in first-degree relatives in Brazil.

ABSTRACT:

Background

Familial aggregation in childhood leukemia is associated with epidemiological and genomic factors. Albeit epidemiological studies on the familial history of hematological malignancies (FHHMs) are scarce, genome-wide studies have identified inherited gene variants associated with leukemia risk. We revisited a dataset of acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) patients to explore the familial aggregation of malignancies among their relatives.

Methods

A series of 5,878 childhood leukemia (≤21 years of age) from the EMiLI study (2000-2019) were assessed. Lack of well-documented familial history of cancer (FHC) and 670 cases associated with genetic phenotypic syndromes were excluded. Leukemia subtypes were established according to World Heal

SUBMITTER: Mendes-de-Almeida DP 

PROVIDER: S-EPMC10322205 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature