Diabetes, metformin use, and survival in esophageal cancer: a population-based cohort study.

ABSTRACT:

Background

It is unclear how diabetes and metformin use is associated with survival of esophageal cancer.

Methods

This population-based cohort study included new cases of esophageal cancer reported in Sweden from 2006 to 2018 with follow-up through 2019. Diabetes status and metformin use were analyzed in relation to all-cause and disease-specific mortality using multivariable Cox regression. The hazard ratios (HRs) with 95% confidence intervals (CIs) were adjusted for age, sex, calendar year, obesity, comorbidity, and use of nonsteroidal anti-inflammatory drugs or statins. For comparison reasons, 3 other antidiabetic medications were also analyzed (ie, sulfonylureas, insulin, and thiazolidinedione).

Results

Among 4851 esophageal cancer patients (8404 person-years), 40

SUBMITTER: Wang QL 

PROVIDER: S-EPMC10322653 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature