GDF15 promotes weight loss by enhancing energy expenditure in muscle.

ABSTRACT: Caloric restriction that promotes weight loss is an effective strategy for treating non-alcoholic fatty liver disease and improving insulin sensitivity in people with type 2 diabetes¹. Despite its effectiveness, in most individuals, weight loss is usually not maintained partly due to physiological adaptations that suppress energy expenditure, a process known as adaptive thermogenesis, the mechanistic underpinnings of which are unclear^2,3. Treatment of rodents fed a high-fat diet with recombinant growth differentiating factor 15 (GDF15) reduces obesity and improves glycaemic control through glial-cell-derived neurotrophic factor family receptor α-like (GFRAL)-dependent suppression of food intake^4-7. Here we find that, in addition to suppressing appetite, GDF

SUBMITTER: Wang D 

PROVIDER: S-EPMC10322716 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature