Comparative analysis of deeply phenotyped GBM cohorts of 'short-term' and 'long-term' survivors.

ABSTRACT:

Background

Glioblastoma (GBM) is an aggressive brain cancer that typically results in death in the first 15 months after diagnosis. There have been limited advances in finding new treatments for GBM. In this study, we investigated molecular differences between patients with extremely short (≤ 9 months, Short term survivors, STS) and long survival (≥ 36 months, Long term survivors, LTS).

Methods

Patients were selected from an in-house cohort (GLIOTRAIN-cohort), using defined inclusion criteria (Karnofsky score > 70; age < 70 years old; Stupp protocol as first line treatment, IDH wild type), and a multi-omic analysis of LTS and STS GBM samples was performed.

Results

Transcriptomic analysis of tumour samples identified cilium gene signatures as enriched in LTS. Moreover,

SUBMITTER: Biswas A 

PROVIDER: S-EPMC10322749 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature