The emerging roles of long noncoding RNAs in lymphatic vascular development and disease.

ABSTRACT: Recent advances in RNA sequencing technologies helped uncover what was once uncharted territory in the human genome-the complex and versatile world of long noncoding RNAs (lncRNAs). Previously thought of as merely transcriptional "noise", lncRNAs have now emerged as essential regulators of gene expression networks controlling development, homeostasis and disease progression. The regulatory functions of lncRNAs are broad and diverse, and the underlying molecular mechanisms are highly variable, acting at the transcriptional, post-transcriptional, translational, and post-translational levels. In recent years, evidence has accumulated to support the important role of lncRNAs in the development and functioning of the lymphatic vasculature and associated pathological processes such as tumor-indu

SUBMITTER: Ivanov KI 

PROVIDER: S-EPMC10322780 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature