In vitro and in silico studies of the antiviral activity of polyhydrated fullerenes against influenza A (H1N1) virus.

ABSTRACT: As of today, influenza viruses remain a relevant target for the development of antiviral compounds due to their rapid evolution and acquisition of the resistance to existing drugs. Fullerene derivatives have already shown the ability to successfully interact with viruses, and polyhydrated fullerenes (or fullerenols) are particularly attractive due to their compatibility with biological fluids and low toxicity. Therefore, the goal of this work was to study the effect of two batches of a mixture of polyhydrated fullerenes with a mass ratio of 78.1% C₆₀/C₇₀ and 21.9% C₇₆/C₇₈/C₈₄ on the influenza A (H1N1) virus. It was determined that the mixture of fullerenols, along with the low toxicity, showed high antiviral activity with a decrease in

SUBMITTER: Zaremba P 

PROVIDER: S-EPMC10322859 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature