Multi-nuclear sodium, diffusion, and perfusion MRI in human gliomas.

ABSTRACT:

Purpose

There is limited knowledge about the associations between sodium and proton MRI measurements in brain tumors. The purpose of this study was to quantify intra- and intertumoral correlations between sodium, diffusion, and perfusion MRI in human gliomas.

Methods

Twenty glioma patients were prospectively studied on a 3T MRI system with multinuclear capabilities. Three mutually exclusive tumor volumes of interest (VOIs) were segmented: contrast-enhancing tumor (CET), T2/FLAIR hyperintense non-enhancing tumor (NET), and necrosis. Median and voxel-wise associations between apparent diffusion coefficient (ADC), normalized relative cerebral blood volume (nrCBV), and normalized sodium measurements were quantified for each VOI.

Results

Both relative sodium concentration

SUBMITTER: Cho NS 

PROVIDER: S-EPMC10322966 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature