Control of sustained attention and impulsivity by G_q-protein signalling in parvalbumin interneurons of the anterior cingulate cortex.

ABSTRACT: The anterior cingulate cortex (ACC) has been implicated in attention deficit hyperactivity disorder (ADHD). More specifically, an appropriate balance of excitatory and inhibitory activity in the ACC may be critical for the control of impulsivity, hyperactivity, and sustained attention which are centrally affected in ADHD. Hence, pharmacological augmentation of parvalbumin- (PV) or somatostatin-positive (Sst) inhibitory ACC interneurons could be a potential treatment strategy. We, therefore, tested whether stimulation of G_q-protein-coupled receptors (G_qPCRs) in these interneurons could improve attention or impulsivity assessed with the 5-choice-serial reaction-time task in male mice. When challenging impulse control behaviourally or pharmacologically, activation of the

SUBMITTER: Jendryka MM 

PROVIDER: S-EPMC10323001 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature