The histone demethylase Utx controls CD8⁺ T-cell-dependent antitumor immunity via epigenetic regulation of the effector function.

ABSTRACT: CD8⁺ T cells play a central role in antitumor immune responses. Epigenetic gene regulation is essential to acquire the effector function of CD8⁺ T cells. However, the role of Utx, a demethylase of histone H3K27, in antitumor immunity remains unclear. In this study, we examined the roles of Utx in effector CD8⁺ T-cell differentiation and the antitumor immune response. In a murine tumor-bearing model, an increased tumor size and decreased survival rate were observed in T-cell-specific Utx KO (Utx KO) mice compared with wild-type (WT) mice. The number of CD8⁺ T cells in tumor-infiltrating lymphocytes (TILs) was significantly decreased in Utx KO mice. We found that the acquisition of effector function was delayed and attenuated in Utx KO CD8⁺

SUBMITTER: Noda H 

PROVIDER: S-EPMC10323087 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature