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Autophagy and cancer: Basic mechanisms and inhibitor development.

ABSTRACT: Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to cellular homeostasis through the turnover of various biomolecules and organelles, often in a selective manner. Autophagy is closely related to cancer, but its roles in cancer are complicated. It works as either a promoter or suppressor, depending on the stage and type of cancer. In this review, we briefly summarize the basic mechanisms of autophagy and describe the complicated roles of autophagy in cancer. Moreover, we summarize the clinical trials of autophagy inhibitors targeting cancer and the development of more specific autophagy inhibitors for future clinical application.

SUBMITTER: Hama Y

PROVIDER: S-EPMC10323110 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature

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Autophagy and cancer: Basic mechanisms and inhibitor development.

Hama Yutaro Y Ogasawara Yuta Y Noda Nobuo N NN

Cancer science 20230420 7

Autophagy is a lysosomal degradation system of cytoplasmic components that contributes to cellular homeostasis through the turnover of various biomolecules and organelles, often in a selective manner. Autophagy is closely related to cancer, but its roles in cancer are complicated. It works as either a promoter or suppressor, depending on the stage and type of cancer. In this review, we briefly summarize the basic mechanisms of autophagy and describe the complicated roles of autophagy in cancer. ...[more]

PMID: 37010190

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