Body mass index and esophageal and gastric cancer: A pooled analysis of 10 population-based cohort studies in Japan.

ABSTRACT: The effect of body mass index (BMI) on esophageal and gastric carcinogenesis might be heterogeneous, depending on subtype or subsite. However, findings from prospective evaluations of BMI associated with these cancers among Asian populations have been inconsistent and limited, especially for esophageal adenocarcinoma and gastric cardia cancer. We performed a pooled analysis of 10 population-based cohort studies to examine this association in 394,247 Japanese individuals. We used Cox proportional hazards regression to estimate study-specific hazard ratios (HRs) and 95% confidence intervals (CIs), then pooled these estimates to calculate summary HRs with a random effects model. During 5,750,107 person-years of follow-up, 1569 esophageal cancer (1038 squamous cell carcinoma and 86 adenocarcin

SUBMITTER: Koyanagi YN 

PROVIDER: S-EPMC10323111 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature