Therapeutic potential of pentamidine for glioma-initiating cells and glioma cells through multimodal antitumor effects.

ABSTRACT: Glioma-initiating cells, which comprise a heterogeneous population of glioblastomas, contribute to resistance against aggressive chemoradiotherapy. Using drug reposition, we investigated a therapeutic drug for glioma-initiating cells. Drug screening was undertaken to select candidate agents that inhibit proliferation of two different glioma-initiating cells lines. The alteration of proliferation and stemness of the two glioma-initiating cell lines, and proliferation, migration, cell cycle, and survival of these two differentiated glioma-initiating cell lines and three different glioblastoma cell lines treated with the candidate agent were evaluated. We also used a xenograft glioma mouse model to evaluate anticancer effects of treated glioma cell lines. Among the 1301 agents, pentamidine-an

SUBMITTER: Tamai S 

PROVIDER: S-EPMC10323113 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature