Accelerating open modification spectral library searching on tensor core in high-dimensional space.

ABSTRACT:

Motivation

Driven by technological advances, the throughput and cost of mass spectrometry (MS) proteomics experiments have improved by orders of magnitude in recent decades. Spectral library searching is a common approach to annotating experimental mass spectra by matching them against large libraries of reference spectra corresponding to known peptides. An important disadvantage, however, is that only peptides included in the spectral library can be found, whereas novel peptides, such as those with unexpected post-translational modifications (PTMs), will remain unknown. Open modification searching (OMS) is an increasingly popular approach to annotate modified peptides based on partial matches against their unmodified counterparts. Unfortunately, this leads to very large search spa

SUBMITTER: Kang J 

PROVIDER: S-EPMC10323168 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature