Post-traumatic osteoarthritis: A review of pathogenic mechanisms and novel targets for mitigation.

ABSTRACT: Post-traumatic osteoarthritis (PTOA) develops secondary to a joint injury and accounts for 12 % of all osteoarthritis. These injuries, often of the lower extremity joints, occur due to trauma or accidents related to athletic or military activities. They primarily affect younger individuals although PTOA can occur across the spectrum of age. Pain and functional disability caused by PTOA confer a heavy economic toll on patients, in addition to detrimentally affecting their quality of life. Both high energy injuries that cause articular surface fracture with or without subchondral bone disruption and low-energy injuries involving joint dislocations or ligamentous injury cause PTOA, albeit through different mechanisms. Regardless, chondrocyte death, mitochondrial dysfunction, reactive oxygen s

SUBMITTER: Dilley JE 

PROVIDER: S-EPMC10323219 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature