Pravastatin reduces plasma levels of extracellular vesicles in pregnancies at high risk of term preeclampsia.

ABSTRACT: Introduction: Elevated plasma levels of extracellular vesicles have been associated with impaired placentation, angiogenesis imbalance, intravascular inflammation, and endothelial dysfunction in women with preeclampsia, thus suggesting that circulating vesicles may be a good therapeutic target for the treatment of the disease. Recently, statins have been considered a potential treatment for the prevention of preeclampsia because of their pleiotropic effects, including the improvement of endothelial dysfunction and inhibition of inflammatory responses. However, the effects of these drugs on circulating vesicles concentration in women at risk of preeclampsia have not been established. Herein, we aimed to assess the effects of pravastatin on circulating extracellular vesicle generation

SUBMITTER: Santoyo JM 

PROVIDER: S-EPMC10323224 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature