A chromatin remodelling SWI/SNF subunit, Snr1, regulates neural stem cell determination and differentiation.

ABSTRACT: Coordinated spatio-temporal regulation of the determination and differentiation of neural stem cells is essential for brain development. Failure to integrate multiple factors leads to defective brain structures or tumour formation. Previous studies suggest changes of chromatin state are needed to direct neural stem cell differentiation, but the mechanisms are unclear. Analysis of Snr1, the Drosophila orthologue of SMARCB1, an ATP-dependent chromatin remodelling protein, identified a key role in regulating the transition of neuroepithelial cells into neural stem cells and subsequent differentiation of neural stem cells into the cells needed to build the brain. Loss of Snr1 in neuroepithelial cells leads to premature neural stem cell formation. Additionally, loss of Snr1 in neural stem cells

SUBMITTER: Keegan SE 

PROVIDER: S-EPMC10323235 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature