The oxoglutarate dehydrogenase complex is involved in myofibril growth and Z-disc assembly in Drosophila.

ABSTRACT: Myofibrils are long intracellular cables specific to muscles, composed mainly of actin and myosin filaments. The actin and myosin filaments are organized into repeated units called sarcomeres, which form the myofibrils. Muscle contraction is achieved by the simultaneous shortening of sarcomeres, which requires all sarcomeres to be the same size. Muscles have a variety of ways to ensure sarcomere homogeneity. We have previously shown that the controlled oligomerization of Zasp proteins sets the diameter of the myofibril. Here, we looked for Zasp-binding proteins at the Z-disc to identify additional proteins coordinating myofibril growth and assembly. We found that the E1 subunit of the oxoglutarate dehydrogenase complex localizes to both the Z-disc and the mitochondria, and is recruited to

SUBMITTER: Gonzalez Morales N 

PROVIDER: S-EPMC10323237 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature