Histopathological subtyping of high-grade serous ovarian cancer using whole slide imaging.

ABSTRACT:

Objective

We have established 4 histopathologic subtyping of high-grade serous ovarian cancer (HGSOC) and reported that the mesenchymal transition (MT) type has a worse prognosis than the other subtypes. In this study, we modified the histopathologic subtyping algorithm to achieve high interobserver agreement in whole slide imaging (WSI) and to characterize the tumor biology of MT type for treatment individualization.

Methods

Four observers performed histopathological subtyping using WSI of HGSOC in The Cancer Genome Atlas data. As a validation set, cases from Kindai and Kyoto Universities were independently evaluated by the 4 observers to determine concordance rates. In addition, genes highly expressed in MT type were examined by gene ontology term analysis. Immunohistochem

SUBMITTER: Miyagawa C 

PROVIDER: S-EPMC10323300 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature