Th2 cells infiltrating high-grade serous ovarian cancer: a feature that may account for the poor prognosis.

ABSTRACT:

Objective

We aimed to investigate the differences of transcriptome profile between 2 groups of high-grade serous ovarian cancer (HGSOC) patients with distinct outcomes and identify potential biomarkers for recurrence.

Methods

RNA sequencing was performed in 2 groups of HGSOC patients with similar demographic characteristics but exhibiting distinct progression-free survival (PFS). Transcriptome data of poor response (PR; PFS ≤6 months) and good response (GR; PFS ≥12 months) group were compared. We employed xCell to evaluate the abundance of 63 cells in tumor microenvironment. The predictive value of recurrence-related tumor infiltration cells was validated in cohort data from Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) dataset. The weighted correlation ne

SUBMITTER: Su H 

PROVIDER: S-EPMC10323303 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature