Exploring novel aryl/heteroaryl-isosteres of phenylthiazole against multidrug-resistant bacteria.

ABSTRACT: Antimicrobial resistance has become a concern as a worldwide threat. A novel scaffold of phenylthiazoles was recently evaluated against multidrug-resistant Staphylococci to control the emergence and spread of antimicrobial resistance, showing good results. Several structural modifications are needed based on the structure-activity relationships (SARs) of this new antibiotic class. Previous studies revealed the existence of two key structural features essential for the antibacterial activity, the guanidine head and lipophilic tail. In this study, a new series of twenty-three phenylthiazole derivatives were synthesized utilizing the Suzuki coupling reaction to explore the lipophilic part. The in vitro antibacterial activity was evaluated against a range of clinical isolates. Th

SUBMITTER: Omara M 

PROVIDER: S-EPMC10323310 | biostudies-literature | 2023 Jun

REPOSITORIES: biostudies-literature