Probabilistic estimation for across-batch compatibility enhancement for amyloid PET.

ABSTRACT:

Introduction

It is necessary to accurately account for systematic differences due to variability in scanners, radiotracers, and acquisition protocols in multisite studies combining amyloid imaging data.

Methods

We propose Probabilistic Estimation for Across-batch Compatibility Enhancement (PEACE), a fully Bayesian multimodal extension of the widely used ComBat harmonization model, and we apply it to harmonize regional amyloid positron emission tomography data from two scanners.

Results

Simulations show that PEACE recovers true harmonized values better than ComBat, even for unimodal data. PEACE harmonization of multiscanner regional amyloid imaging data yields results that agree better with longitudinal data compared to ComBat, without removing the known biological eff

SUBMITTER: Bilgel M 

PROVIDER: S-EPMC10323321 | biostudies-literature | 2023 Jul-Sep

REPOSITORIES: biostudies-literature