Salivary Gland Uptake on ¹⁸F-FP-CIT PET as a New Biomarker in Patients With Parkinsonism.

ABSTRACT:

Objective

¹⁸F-FP-CIT positron emission tomography (PET) is known for its high sensitivity and specificity for evaluating striatal dopamine transporter (DAT) binding. Recently, for the early diagnose of Parkinson's disease, many researchers focused on the diagnosis of synucleinopathy in organs involved in non-motor symptoms of Parkinson's disease. We investigated the feasibility of salivary gland uptake on ¹⁸F-FP-CIT PET as a new biomarker in patients with parkinsonism.

Materials and methods

A total of 219 participants with confirmed or presumed parkinsonism, including 54 clinically diagnosed idiopathic Parkinson's disease (IPD), 59 suspected and yet undiagnosed, and 106 with secondary parkinsonism, were enrolled. The standardized uptake value ratio (SUV

SUBMITTER: Kang SY 

PROVIDER: S-EPMC10323421 | biostudies-literature | 2023 Jul

REPOSITORIES: biostudies-literature