Galantamine ameliorates hyperoxia-induced brain injury in neonatal mice.

ABSTRACT:

Introduction

Prolonged oxygen therapy in preterm infants often leads to cognitive impairment. Hyperoxia leads to excess free radical production with subsequent neuroinflammation, astrogliosis, microgliosis and apoptosis. We hypothesized that Galantamine, an acetyl choline esterase inhibitor and an FDA approved treatment of Alzheimer's disease, will reduce hyperoxic brain injury in neonatal mice and will improve learning and memory.

Methods

Mouse pups at postnatal day 1 (P1) were placed in a hyperoxia chamber (FiO₂ 95%) for 7 days. Pups were injected IP daily with Galantamine (5 mg/kg/dose) or saline for 7 days.

Results

Hyperoxia caused significant neurodegeneration in cholinergic nuclei of the basal forebrain cholinergic system (BFCS), laterodorsal tegmenta

SUBMITTER: Zaghloul N 

PROVIDER: S-EPMC10323435 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature