Torque teno virus viremia and QuantiFERON^®-CMV assay in prediction of cytomegalovirus reactivation in R+ kidney transplant recipients.

ABSTRACT:

Introduction

Cytomegalovirus (CMV) is the most frequent infectious complication following solid organ transplantation. Torque teno viruses (TTV) viremia has been proposed as a biomarker of functional immunity in the management of kidney transplant recipients (KTR). The QuantiFERON^®-CMV (QF-CMV) is a commercially available assay that allows the assessment of CD8⁺ T-cell responses in routine diagnostic laboratories.

Methods

In a prospective national multicenter cohort of 64 CMV-seropositive (R+) KTR, we analyzed the value of TTV load and the two markers of the QF-CMV assay [QF-Ag (CMV-specific T-cell responses) and QF-Mg (overall T-cell responses)], alone and in combination, in prediction of CMV reactivation (≥3 log₁₀ IU/ ml) in the first post-

SUBMITTER: Mafi S 

PROVIDER: S-EPMC10323437 | biostudies-literature | 2023

REPOSITORIES: biostudies-literature